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As the NIH pursues such top-down changes, one company is taking a bottom-up approach, targeting scientists directly to see if they are willing to verify their experiments.There is the looming question, however, of who will pay for it all.In biomedical science, at least one thing is apparently reproducible: a steady stream of studies that show the irreproducibility of many important experiments.In a 2011 internal survey, pharmaceutical firm Bayer Health Care of Leverkusen, Germany, was unable to validate the relevant preclinical research for almost two-thirds of 67 in-house projects.Then, in 2012, scientists at Amgen, a drug company based in Thousand Oaks, California, reported their failure to replicate 89% of the findings from 53 landmark cancer papers.And in a study published in May, more than half of the respondents to a survey at the MD Anderson Cancer Center in Houston, Texas, reported failing at least once in attempts at reproducing published data (see 'Make believe').Some of them return failures for harmful or malicious sites.

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Reproducibility problems have led the National Institutes of Health to consider verification rules for some experiments.

September 2011 Bayer Health Care finds inconsistencies between in-house and published data in almost two-thirds of 67 projects.

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Background: Although researchers have evaluated nurse competence in past studies, few have focused on the compe- tence levels of nursing students immediately prior to graduation.